Seminar Prof. Dr. Tamara Bidone - Multiscale models of integrin and integrin adhesions: from all-atom to macromolecular and mesoscale simulations

Integrins are single pass alpha/beta heterodimeric transmembrane receptors that physically connect the extracellular matrix to the cell cytoskeleton, thus integrating internal and external environments.  Integrins undergo dynamic transitions from bent (inactive) to extended (active) conformations, which correspond to an increase in ligand binding affinity and adhesions assembly. These structural transitions require a remarkable convergence of interactions and influences.